If you’re hoping to clean out the Windows registry on your computer then I highly recommend getting the best software you can.  The reason for this is that the registry is a very important part of your computer, and removing the wrong entries can definitely cripple it.  I recommend looking into getting a good registry cleaner such as RegCure.  The best registry cleaner for Vista is one that actually says that it is certified for Vista.  If you’re running Vista then don’t get a cleaner that’s not certified to work with it.  Otherwise you could run into problems.